Craighead Research Group News http://www.hgc.cornell.edu Recent publications and news highlights from the research group of Prof. Harold Craighead at Cornell University http://www.hgc.cornell.edu/images/minihgclogo.gif Craighead Research Group News http://www.hgc.cornell.edu en-us cgroup.webmaster@gmail.com (Craighead Group Webmaster) Fri, 20 Nov 2009 15:42:00 EDT Recent work featured on the cover of Integrative Biology http://www.rsc.org/Publishing/Journals/IB/Index.asp paper on parylene peel arrays for cell patterning has been featured on the cover of Volume 1 Issue 10.

]]> http://www.rsc.org/Publishing/Journals/IB/article.asp?doi=b918974m Parylene technology focus http://www.genengnews.com/articles/chitem.aspx?aid=3070&pn=3 http://www.genengnews.com/articles/chitem.aspx?aid=3070&pn=3 Piezoresistive transduction in multilayer polycrystalline silicon resonators http://link.aip.org/link/?APPLAB/95/133113/1 et al. in the journal Applied Physics Letters. These resonators, fabricated from highly doped polycrystalline silicon layers separated by a dielectric layer, effectively transduces their mechanical motion as a vertical piezoresistor.]]> http://link.aip.org/link/?APPLAB/95/133113/1 Poster award at Cornell NanoScale Facility Annual Meeting http://www.hgc.cornell.edu/news/news.htm#benny http://www.hgc.cornell.edu/news/news.htm#benny A method for nanofluidic device prototyping using elastomeric collapse http://www.pnas.org/cgi/doi/10.1073/pnas.0904004106 et al. in the journal PNAS, demonstrating a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures.]]> http://www.pnas.org/cgi/doi/10.1073/pnas.0904004106 Labeling and Purification of Cellulose-Binding Proteins for High Resolution Fluorescence Applications http://pubs.acs.org/doi/abs/10.1021/ac901183b et al. in the journal Analytical Chemistry, demonstrating a new protocol for labeling cellulases with three different fluorophores and their purification and separation of the labeled products.]]> http://pubs.acs.org/doi/abs/10.1021/ac901183b Parylene peel-off arrays to probe the role of cell cell interactions in tumour angiogenesis http://xlink.rsc.org/?doi=B908036H et al. in the journal Integrative Biology. This work uses parylene as a stencil in order to pattern arrays of material which cells preferentially bind to. By simply varying the size and spacing of these arrays, the communication between single and groups of cells can be studied as a function of cell number and spacing, which should continue to give insights into tumor cell behavior and angiogenesis.]]> http://xlink.rsc.org/?doi=B908036H Detection of prostate specific antigen with nanomechanical resonators http://www.rsc.org/Publishing/Journals/LC/article.asp?doi=b907309b et al. in the journal Lab on a Chip, demonstrating the detection of prostate specific antigen, a biomarker used for prostate cancer detection. The molecule could be detected at concentrations as low as 50 fg/mL (1.5 fM) in undiluted serum.]]> http://www.rsc.org/Publishing/Journals/LC/article.asp?doi=b907309b Prion Protein detection in serum using micromechanical resonator arrays http://dx.doi.org/10.1016/j.talanta.2009.07.032 et al. in the journal Talanta, demonstrating the detection of Prion proteins in serum using secondary mass labeling.]]> http://dx.doi.org/10.1016/j.talanta.2009.07.032 Micromechanical drumhead resonators for pressure sensing http://link.aip.org/link/?APL/94/213506 et al. entitled, "Pressure dependent resonant frequency of micromechanical drumhead resonators," in Applied Physics Letters. These devices were found to be excellent pressure sensors, giving a linear response in frequency shift from pressures of roughly one hundredth of an atmosphere up to nearly 4 atmospheres.]]> http://link.aip.org/link/?APL/94/213506 Recent research selected for inclusion in the Virtual Journal of Nanoscale Science and Technology http://www.vjnano.org/ A paper recently published by P. S. Waggoner et al., High-Q, in-plane modes of nanomechanical resonators operated in air, has been chosen for virtual publication in the May 18th issue of the Virtual Journal of Nanoscale Science and Technology, published by the AIP and APS in cooperation with others to compile outstanding research in this field across many journals.

This marks the second publication from the Craighead Group recently highlighted in this virtual journal, joining the recently published The relationship between material properties, device design, and the sensitivity of resonant mechanical sensors, included in the March 23rd issue.

]]> http://www.hgc.cornell.edu/news/news.htm#vjnano New paper published on high-Q, in-plane resonators operated in air http://link.aip.org/link/?JAPIAU/105/094315/1 et al. in the Journal of Applied Physics, DOI:10.1063/1.3123767. These trampoline-shaped devices are promising for sensor applications at high/atmospheric pressures, and suggest that this in-plane resonant mode can be beneficial for other resonator designs as well.]]> http://link.aip.org/link/?JAPIAU/105/094315/1 Recent aptamer publication featured as "Hot Article" by RSC http://www.rsc.org/publishing/journals/LC/HotArticles.asp et al. in Lab on a Chip DOI:10.1039/b819905a has been featured on the Royal Society of Chemistry website as a "Hot Article." This work describes a microfluidic device used to select and purify aptamers using individually addressable sol-gel capture droplets which can capture specific aptamers but later be removed with integrated heaters. This chip-based method shows promising results for improving the way aptamers are developed and prepared.]]> http://www.hgc.cornell.edu/news/news.htm#hotaptamer Sugar-based microfluidics paper featured on cover of Soft Matter http://www.rsc.org/Publishing/Journals/SM/article.asp?doi=b904901k et al. using cotton candy to form dense microfluidic channels for artificial tissue in Soft Matter DOI:10.1039/b819905a has been featured on the front cover of issue 7 (Vol. 5, 2009).]]> http://www.rsc.org/Publishing/Journals/SM/article.asp?doi=b904901k The Relationship Between Material Properties, Device Design, and the Sensitivity of Resonant Mechanical Sensors http://link.aip.org/link/?JAPIAU/105/054306/1 A new paper has been published by Philip S. Waggoner and Harold G. Craighead in the Journal of Applied Physics, DOI:10.1063/1.3079793, looking into how resonator design affects the detection mechanism and sensitivity of the sensor. Notably, traditional cantilever devices were shown to not always be the most sensitive, and it was suggested that in most resonant biosensing applications, only the bound mass would be detected rather than stiffness.]]> http://link.aip.org/link/?JAPIAU/105/054306/1 RSS 2.0 Feed added to Website http://www.hgc.cornell.edu/news/news.htm Recent news and publications from the Craighead research group will now be available through an RSS 2.0 feed. Subscribe at here]]> or on the group website. http://www.hgc.cornell.edu/news/hgcnews.xml