Craighead Research Group News http://www.hgc.cornell.edu Recent publications and news highlights from the research group of Prof. Harold Craighead at Cornell University http://www.hgc.cornell.edu/images/minihgclogo.gif Craighead Research Group News http://www.hgc.cornell.edu en-us cgroup.webmaster@gmail.com (Craighead Group Webmaster) Fri, 20 Nov 2009 15:42:00 EDT Synchronous imaging for rapid visualization of complex vibration profiles in electromechanical microresonators http://jap.aip.org/resource/1/japiau/v111/i2/p023507_s1 et al. in the journal Journal of Applied Physics, presenting experimental study of high drive amplitude and ambient pressure effect on the resonant vibration profiles in electrically driven microbridges near critical buckling.]]> http://jap.aip.org/resource/1/japiau/v111/i2/p023507_s1 Modal dependence of dissipation in silicon nitride drum resonators http://apl.aip.org/resource/1/applab/v99/i25/p253103_s1 et al. in the journal Applied Physics Letters, showing that the dissipation of large diameter high tensile stress SiN membrane mechanical resonators is limited by clamping loss for pure radial modes, but higher order azimuthal modes are limited by a mechanism which appears to be intrinsic to the material.]]> http://apl.aip.org/resource/1/applab/v99/i25/p253103_s1 Single DNA molecule patterning for high-throughput epigenetic mapping http://pubs.acs.org/doi/abs/10.1021/ac202506j et al. in the journal Analytical Chemistry, presenting a method for profiling the 5-methyl cytosine distribution on single DNA molecules.]]> http://pubs.acs.org/doi/abs/10.1021/ac202506j Transfer-printing of single DNA molecule arrays on graphene for high-resolution electron imaging and analysis http://pubs.acs.org/doi/abs/10.1021/nl202219w et al. in the journal Nano Letters, presenting a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis.]]> http://pubs.acs.org/doi/abs/10.1021/nl202219w Fabrication and performance of graphene nanoelectromechanical systems http://avspublications.org/jvstb/resource/1/jvtbd9/v29/i5/p050801_s1 et al. in the journal Journal of Vacuum Science and Technology B. The article reviews the progress of resonant graphene nanoelectromechanical systems and the possible applications of the technology to signal processing, sensing, and other areas.]]> http://avspublications.org/jvstb/resource/1/jvtbd9/v29/i5/p050801_s1 An array of planar apertures for near-field fluorescence correlation spectroscopy http://www.cell.com/biophysj/abstract/S0006-3495(11)00252-9 et al. in the journal Biophysical Journal, showing a method of performing near-field fluorescence correlation spectroscopy to demonstrate the sub-diffraction-limited illumination with an array of planarized circular apertures of 50 nm diameter.]]> http://www.cell.com/biophysj/abstract/S0006-3495(11)00252-9 Observing Thermobifida fusca cellulase binding to pretreated wood particles using time-lapse confocal laser scanning microscopy http://www.springerlink.com/content/w04pm341878j3g67 et al. in the journal Cellulose, reporting on studies of Thermobifida fusca cellulases Cel5A, Cel6B and Cel9A binding to pretreated wood particles using Confocal Laser Scanning Microscopy (CLSM).]]> http://www.springerlink.com/content/w04pm341878j3g67 High, size-dependent quality factor in an array of graphene mechanical resonators http://pubs.acs.org/doi/abs/10.1021/nl1042227 et al. in the journal Nano Letters, demonstrating a striking improvement quality factor of circular graphene membrane resonators grown by chemical vapor deposition with increasing diameter.]]> http://pubs.acs.org/doi/abs/10.1021/nl1042227 High-Q nanomechanics via destructive interference of elastic waves http://prl.aps.org/abstract/PRL/v106/i4/e047205 et al. in the journal Physical Review Letters, showing that for azimuthal harmonics of the circular geometry destructive interference of the radiated waves leads to an exponential suppression of the clamping loss in the harmonic index.]]> http://prl.aps.org/abstract/PRL/v106/i4/e047205 Recent work featured in Technology Review http://www.technologyreview.com/computing/26794 paper on single-layer graphene resonator arrays has been featured in technology review.]]> http://www.technologyreview.com/computing/26794 Large-scale arrays of single-layer graphene resonators http://pubs.acs.org/doi/abs/10.1021/nl102713c et al. in the journal Nano Letters, demonstrating that it is possible to produce large arrays of CVD-grown graphene resonators with reproducible properties.]]> http://pubs.acs.org/doi/abs/10.1021/nl102713c Microfluidic integration of nanomechanical resonators for protein analysis in serum http://dx.doi.org/10.1016/j.snb.2010.08.041 et al. in the journal Sensors and Actuators B, presenting a technique for reversibly encapsulating nanomechanical resonant sensors within microfluidic channels that are reusable and easy to fabricate.]]> http://dx.doi.org/10.1016/j.snb.2010.08.041 Rapid prototyping of nanofluidic systems using size-reduced electrospun nanofibers for biomolecular analysis http://onlinelibrary.wiley.com/doi/10.1002/smll.201000884/abstract et al. in the journal Small, demonstrating a new method for fabricating nanofluidic systems from size-reduced electrospun nanofibers.]]> http://onlinelibrary.wiley.com/doi/10.1002/smll.201000884/abstract Revisiting the conformation and dynamics of DNA in slitlike confinement http://pubs.acs.org/doi/abs/10.1021/ma101157x et al. in the journal Macromolecules, experimentally investigating the equilibrium conformation and dynamics of single DNA molecules in slitlike nanochannels.]]> http://pubs.acs.org/doi/abs/10.1021/ma101157x Real-time synchronous imaging of electromechanical resonator mode and equilibrium profiles http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-15-2654 et al. in the journal Optics Letters, showing that profiles of mechanical modes in suspended thin film structures are measured through all-optical Fabry-Perot reflectance fits to the temporal traces.]]> http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-15-2654 Atomic layer deposited silicon dioxide films on nanomechanical silicon nitride resonators http://jap.aip.org/japiau/v107/i11/p114505_s1 et al. in the journal Journal of Applied Physics, presenting experimental data and an analytical model for the effect of atomic layer deposition (ALD) growth of thin silicon dioxide films deposited on nanomechanical resonators and their effect on the resonant properties of silicon nitride devices as a function of thickness.]]> http://jap.aip.org/japiau/v107/i11/p114505_s1 Fabrication of a nanomechanical mass sensor containing a nanofluidic channel http://pubs.acs.org/doi/abs/10.1021/nl100193g et al. in the journal Nano Letters, showing the performance of doubly clamped beam resonators that contain filled nanofluidic channels. The resonators operate at frequencies on the order of 25 MHz and when filled with fluid have quality factors as high as 800, two orders of magnitude higher than that of resonators of comparable size and frequency operating in fluid.]]> http://pubs.acs.org/doi/abs/10.1021/nl100193g Stress-based vapor sensing using resonant microbridges http://apl.aip.org/applab/v96/i16/p163503_s1 et al. in the journal Applied Physics Letters, demonstrating stress-based sensing of water vapor in ambient pressure nitrogen using doubly clamped buckled beams coated with a hygroscopic polymer.]]> http://apl.aip.org/applab/v96/i16/p163503_s1 Surface engineering and patterning using parylene for biological applications http://www.mdpi.com/1996-1944/3/3/1803 et al. in the journal Materials. In this article, the emerging role and applications of parylene as a biomaterial for surface chemical modification are reviewed.]]> http://www.mdpi.com/1996-1944/3/3/1803 Single molecule epigenetic analysis in a nanofluidic channel http://pubs.acs.org/doi/abs/10.1021/ac9028642 et al. in the journal Analytical Chemistry, demostrating a method using nanofluidics and multicolor fluorescence microscopy to detect DNA and histones in individual chromatin fragments at about 10 Mbp/min.]]> http://pubs.acs.org/doi/abs/10.1021/ac9028642 Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off http://pubs.acs.org/doi/full/10.1021/nl903968s et al. in the journal Nano Letters, presenting a high-throughtput method known as "Print-and-Peel" to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width.]]> http://pubs.acs.org/doi/full/10.1021/nl903968s DNA manipulation, sorting, and mapping in nanofluidic systems http://www.rsc.org/Publishing/Journals/CS/article.asp?doi=b820266b et al. in the journal Chemical Society Reviews. In this article, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed.]]> http://www.rsc.org/Publishing/Journals/CS/article.asp?doi=b820266b Recent work featured on the cover of Integrative Biology http://www.rsc.org/Publishing/Journals/IB/Index.asp paper on parylene peel arrays for cell patterning has been featured on the cover of Volume 1 Issue 10.

]]> http://www.rsc.org/Publishing/Journals/IB/article.asp?doi=b918974m Parylene technology focus http://www.genengnews.com/articles/chitem.aspx?aid=3070&pn=3 http://www.genengnews.com/articles/chitem.aspx?aid=3070&pn=3 Piezoresistive transduction in multilayer polycrystalline silicon resonators http://link.aip.org/link/?APPLAB/95/133113/1 et al. in the journal Applied Physics Letters. These resonators, fabricated from highly doped polycrystalline silicon layers separated by a dielectric layer, effectively transduces their mechanical motion as a vertical piezoresistor.]]> http://link.aip.org/link/?APPLAB/95/133113/1 Poster award at Cornell NanoScale Facility Annual Meeting http://www.hgc.cornell.edu/news/news.htm#benny http://www.hgc.cornell.edu/news/news.htm#benny A method for nanofluidic device prototyping using elastomeric collapse http://www.pnas.org/cgi/doi/10.1073/pnas.0904004106 et al. in the journal PNAS, demonstrating a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures.]]> http://www.pnas.org/cgi/doi/10.1073/pnas.0904004106 Labeling and Purification of Cellulose-Binding Proteins for High Resolution Fluorescence Applications http://pubs.acs.org/doi/abs/10.1021/ac901183b et al. in the journal Analytical Chemistry, demonstrating a new protocol for labeling cellulases with three different fluorophores and their purification and separation of the labeled products.]]> http://pubs.acs.org/doi/abs/10.1021/ac901183b Parylene peel-off arrays to probe the role of cell cell interactions in tumour angiogenesis http://xlink.rsc.org/?doi=B908036H et al. in the journal Integrative Biology. This work uses parylene as a stencil in order to pattern arrays of material which cells preferentially bind to. By simply varying the size and spacing of these arrays, the communication between single and groups of cells can be studied as a function of cell number and spacing, which should continue to give insights into tumor cell behavior and angiogenesis.]]> http://xlink.rsc.org/?doi=B908036H Detection of prostate specific antigen with nanomechanical resonators http://www.rsc.org/Publishing/Journals/LC/article.asp?doi=b907309b et al. in the journal Lab on a Chip, demonstrating the detection of prostate specific antigen, a biomarker used for prostate cancer detection. The molecule could be detected at concentrations as low as 50 fg/mL (1.5 fM) in undiluted serum.]]> http://www.rsc.org/Publishing/Journals/LC/article.asp?doi=b907309b Prion Protein detection in serum using micromechanical resonator arrays http://dx.doi.org/10.1016/j.talanta.2009.07.032 et al. in the journal Talanta, demonstrating the detection of Prion proteins in serum using secondary mass labeling.]]> http://dx.doi.org/10.1016/j.talanta.2009.07.032 Micromechanical drumhead resonators for pressure sensing http://link.aip.org/link/?APL/94/213506 et al. entitled, "Pressure dependent resonant frequency of micromechanical drumhead resonators," in Applied Physics Letters. These devices were found to be excellent pressure sensors, giving a linear response in frequency shift from pressures of roughly one hundredth of an atmosphere up to nearly 4 atmospheres.]]> http://link.aip.org/link/?APL/94/213506 Recent research selected for inclusion in the Virtual Journal of Nanoscale Science and Technology http://www.vjnano.org/ A paper recently published by P. S. Waggoner et al., High-Q, in-plane modes of nanomechanical resonators operated in air, has been chosen for virtual publication in the May 18th issue of the Virtual Journal of Nanoscale Science and Technology, published by the AIP and APS in cooperation with others to compile outstanding research in this field across many journals.

This marks the second publication from the Craighead Group recently highlighted in this virtual journal, joining the recently published The relationship between material properties, device design, and the sensitivity of resonant mechanical sensors, included in the March 23rd issue.

]]> http://www.hgc.cornell.edu/news/news.htm#vjnano New paper published on high-Q, in-plane resonators operated in air http://link.aip.org/link/?JAPIAU/105/094315/1 et al. in the Journal of Applied Physics, DOI:10.1063/1.3123767. These trampoline-shaped devices are promising for sensor applications at high/atmospheric pressures, and suggest that this in-plane resonant mode can be beneficial for other resonator designs as well.]]> http://link.aip.org/link/?JAPIAU/105/094315/1 Recent aptamer publication featured as "Hot Article" by RSC http://www.rsc.org/publishing/journals/LC/HotArticles.asp et al. in Lab on a Chip DOI:10.1039/b819905a has been featured on the Royal Society of Chemistry website as a "Hot Article." This work describes a microfluidic device used to select and purify aptamers using individually addressable sol-gel capture droplets which can capture specific aptamers but later be removed with integrated heaters. This chip-based method shows promising results for improving the way aptamers are developed and prepared.]]> http://www.hgc.cornell.edu/news/news.htm#hotaptamer Sugar-based microfluidics paper featured on cover of Soft Matter http://www.rsc.org/Publishing/Journals/SM/article.asp?doi=b904901k et al. using cotton candy to form dense microfluidic channels for artificial tissue in Soft Matter DOI:10.1039/b819905a has been featured on the front cover of issue 7 (Vol. 5, 2009).]]> http://www.rsc.org/Publishing/Journals/SM/article.asp?doi=b904901k The Relationship Between Material Properties, Device Design, and the Sensitivity of Resonant Mechanical Sensors http://link.aip.org/link/?JAPIAU/105/054306/1 A new paper has been published by Philip S. Waggoner and Harold G. Craighead in the Journal of Applied Physics, DOI:10.1063/1.3079793, looking into how resonator design affects the detection mechanism and sensitivity of the sensor. Notably, traditional cantilever devices were shown to not always be the most sensitive, and it was suggested that in most resonant biosensing applications, only the bound mass would be detected rather than stiffness.]]> http://link.aip.org/link/?JAPIAU/105/054306/1 RSS 2.0 Feed added to Website http://www.hgc.cornell.edu/news/news.htm Recent news and publications from the Craighead research group will now be available through an RSS 2.0 feed. Subscribe at here]]> or on the group website. http://www.hgc.cornell.edu/news/hgcnews.xml