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1 August 2013 Graphene Metallization of High-Stress Silicon Nitride Resonators for Electrical Integration

V.P. Aidga and R. Barton has recently published an article in Nano Letters using graphene as a cotaing for silicon nitride membranes to reduce quality factor.

29 March 2013 Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells

P.J. Murphy, C.B. Wallin, K. Szeto, and J. Benitez has recently published an article in PNASdescribing an approach to simultaneously detect multiple epigenetic marks on a single-molecule level as well as locating specific gene marks in normal and cancer genomes.

13 February 2013 Multiplexed microcolumn-based process for efficient selection of RNA aptamers

K. Szeto and D.R. Latulippe has published a new paper in Analytical Chemistry. The article introduced a high throughput reusable SELEX microcolumn device optimized for multiplex aptamer selections. Both the process and device was demonstrated upon GFP-binding RNA aptamers and later used to perform a multiplex selection to heat shock factor proteins hHSF1 and hHSF2.

5 February 2013 Preservation of Antibody Selectivity on Graphene by Conjugation to a Tripod Monolayer

Congratulations T. Alava for his new paper in Angewandte Chemie describing a tipodal molecule whose non-covalent functionalization of graphene is superior to direct adsorption of biomolecules. Cells showed enhanced binding and proliferation only on tripodal functionalized graphene by preserving the activity and selectivity of adsorbed antibodies.

31 January 2013 Control of the Graphene–Protein Interface Is Required To Preserve Adsorbed Protein Function

Congratulations T. Alava for his new paper in Analytical Chemistry studying the graphene-protein interface and its effect on protein activity. By using a graphene coated QCM, binding strategies of molecules to graphene were monitored and characterized, notably a monolayer of tripod molecules that binds to graphene was shown to preserve the activity of bound proteins.

29 November 2012.

Congratulations to Christopher Kelly on accepting his new position as a faculty member of Wayne State University!

26 September 2012 Approaching intrinsic performance in ultra-thin silicon nitride drum resonators

A new article has been published by V. Adiga et al. in the Journal of App Phys. The article observes that the dissipation of silicon nitride drum resonators are dependent on differing factors according to the resonator thickness.

10 September 2012 Microfluidic Extraction, Stretching and Analysis of Human Chromosomal DNA from Single Cells

A new publication by J. Benitez et al. in Lab-on-a-Chip, demonstrates a device capable of high efficiency DNA extraction from small cell populations for the purposes of either retainment or input into downstream processes.

13 August 2012 Photothermal Self-Oscillation and Laser Cooling of Graphene Optomechanical Systems

Recent publication by R. Barton et al. in the journal,Nano Letters, explores the photothermal back-action in graphene mechanical resonators as a function of optomechanics.

21 July 2012 Ordered Arrays of Native Chromatin Molecules for High-Resolution Imaging and Analysis

Congratulations to A. Cerf et al. on the recent article published in ACS Nano, detailing single molecule chromatin combing and labeling capabilities through the process of molecular combing.

30 May 2012 Stress-based resonant volatile gas microsensor operated near the critically buckled state

A new paper has been published by D. J. Joe et al. in the journal Journal of Applied Physics, describing a method of critically buckled polycrystalline silicon doubly clamped mechanical resonators coated on one side with polymethyl methacrylate (PMMA).

3 April 2012 Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel

A new paper has been published by B. R. Cirpriany et al. in the journal PNAS, present a proof-of-principle demonstration for a new method using a nanofluidic device that combines real-time detection and automated sorting of individual molecules based on their epigenetic state.

20 Jan 2012 Synchronous imaging for rapid visualization of complex vibration profiles in electromechanical microresonators

A new paper has been published by Y. Linzon et al. in the journal Journal of Applied Physics, presenting experimental study of high drive amplitude and ambient pressure effect on the resonant vibration profiles in electrically driven microbridges near critical buckling.

20 Dec 2011 Modal dependence of dissipation in silicon nitride drum resonators

A new paper has been published by V. P. Adiga et al. in the journal Applied Physics Letters, showing that the dissipation of large diameter high tensile stress SiN membrane mechanical resonators is limited by clamping loss for pure radial modes, but higher order azimuthal modes are limited by a mechanism which appears to be intrinsic to the material.

7 Oct 2011 Single DNA molecule patterning for high-throughput epigenetic mapping

A new paper has been published by A. Cerf et al. in the journal Analytical Chemistry, presenting a method for profiling the 5-methyl cytosine distribution on single DNA molecules.

16 Sept 2011 Transfer-printing of single DNA molecule arrays on graphene for high-resolution electron imaging and analysis

A new paper has been published by A. Cerf et al. in the journal Nano Letters, presenting a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis.

9 Sept 2011 Fabrication and performance of graphene nanoelectromechanical systems

A new paper has been published by R. A. Barton et al. in the journal Journal of Vacuum Science and Technology B. The article reviews the progress of resonant graphene nanoelectromechanical systems and the possible applications of the technology to signal processing, sensing, and other areas.

6 Apr 2011 An array of planar apertures for near-field fluorescence correlation spectroscopy

A new paper has been published by C. V. Kelly et al. in the journal Biophysical Journal, showing a method of performing near-field fluorescence correlation spectroscopy to demonstrate the sub-diffraction-limited illumination with an array of planarized circular apertures of 50 nm diameter.

6 Feb 2011 Observing Thermobifida fusca cellulase binding to pretreated wood particles using time-lapse confocal laser scanning microscopy

A new paper has been published by P. Zhu et al. in the journal Cellulose, reporting on studies of Thermobifida fusca cellulases Cel5A, Cel6B and Cel9A binding to pretreated wood particles using Confocal Laser Scanning Microscopy (CLSM).

4 Feb 2011 High, size-dependent quality factor in an array of graphene mechanical resonators

A new paper has been published by R. A. Barton et al. in the journal Nano Letters, demonstrating a striking improvement quality factor of circular graphene membrane resonators grown by chemical vapor deposition with increasing diameter.

27 Jan 2011 High-Q nanomechanics via destructive interference of elastic waves

A new paper has been published by I. Wilson-Rae et al. in the journal Physical Review Letters, showing that for azimuthal harmonics of the circular geometry destructive interference of the radiated waves leads to an exponential suppression of the clamping loss in the harmonic index.

December 2010 Recent work featured in Technology Review

A recent paper on single-layer graphene resonator arrays has been featured in Technology Review.

16 Nov 2010 Large-scale arrays of single-layer graphene resonators

A new paper has been published by A. M. van der Zande et al. in the journal Nano Letters, demonstrating that it is possible to produce large arrays of CVD-grown graphene resonators with reproducible properties.

28 Oct 2010 Microfluidic integration of nanomechanical resonators for protein analysis in serum

A new paper has been published by P. S. Waggoner et al. in the journal Sensors and Actuators B, presenting a technique for reversibly encapsulating nanomechanical resonant sensors within microfluidic channels that are reusable and easy to fabricate.

28 Oct 2010 Microfluidic integration of nanomechanical resonators for protein analysis in serum

A new paper has been published by P. S. Waggoner et al. in the journal Sensors and Actuators B, presenting a technique for reversibly encapsulating nanomechanical resonant sensors within microfluidic channels that are reusable and easy to fabricate.

27 Oct 2010 Honors and Awards from AVS 57th Symposium

Christine Tan received the Russell and Sigurd Varian Award competitively awarded to a top graduate student for excellence in research and academic record. She also received a Young Investigator Award (Biomaterials Interface Division) awarded to researchers under age 35 for her oral presentation.

Philip Waggoner received the First Prize in the Artzone Competition for his SEM image "Walking the Plank."

27 Sept 2010 Rapid prototyping of nanofluidic systems using size-reduced electrospun nanofibers for biomolecular analysis

A new paper has been published by S.-m. Park et al. in the journal Small, demonstrating a new method for fabricating nanofluidic systems from size-reduced electrospun nanofibers.

5 Aug 2010 Revisiting the conformation and dynamics of DNA in slitlike confinement

A new paper has been published by J. Tang et al. in the journal Macromolecules, experimentally investigating the equilibrium conformation and dynamics of single DNA molecules in slitlike nanochannels.

1 Aug 2010 Real-time synchronous imaging of electromechanical resonator mode and equilibrium profiles

A new paper has been published by Y. Linzon et al. in the journal Optics Letters, showing that profiles of mechanical modes in suspended thin film structures are measured through all-optical Fabry-Perot reflectance fits to the temporal traces.

2 June 2010 Atomic layer deposited silicon dioxide films on nanomechanical silicon nitride resonators

A new paper has been published by P. S. Waggoner et al. in the journal Journal of Applied Physics, presenting experimental data and an analytical model for the effect of atomic layer deposition (ALD) growth of thin silicon dioxide films deposited on nanomechanical resonators and their effect on the resonant properties of silicon nitride devices as a function of thickness.

5 May 2010 Fabrication of a nanomechanical mass sensor containing a nanofluidic channel

A new paper has been published by R. A. Barton et al. in the journal Nano Letters, showing the performance of doubly clamped beam resonators that contain filled nanofluidic channels. The resonators operate at frequencies on the order of 25 MHz and when filled with fluid have quality factors as high as 800, two orders of magnitude higher than that of resonators of comparable size and frequency operating in fluid.

20 Apr 2010 Stress-based vapor sensing using resonant microbridges

A new paper has been published by D. R. Southworth et al. in the journal Applied Physics Letters, demonstrating stress-based sensing of water vapor in ambient pressure nitrogen using doubly clamped buckled beams coated with a hygroscopic polymer.

15 Mar 2010 Surface engineering and patterning using parylene for biological applications

A new paper has been published by C. P. Tan et al. in the journal Materials. In this article, the emerging role and applications of parylene as a biomaterial for surface chemical modification are reviewed.

25 Feb 2010 Single molecule epigenetic analysis in a nanofluidic channel

A new paper has been published by B. R. Cipriany et al. in the journal Analytical Chemistry, demostrating a method using nanofluidics and multicolor fluorescence microscopy to detect DNA and histones in individual chromatin fragments at about 10 Mbp/min.

20 Jan 2010 Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off

A new paper has been published by C. P. Tan et al. in the journal Nano Letters, presenting a high-throughtput method known as "Print-and-Peel" to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width.

12 Jan 2010 DNA manipulation, sorting, and mapping in nanofluidic systems

A new paper has been published by S. L. Levy et al. in the journal Chemical Society Reviews. In this article, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed.

October 2009 Recent work featured on the cover of Integrative Biology

A recent paper on parylene peel arrays for cell patterning has been featured on the cover of Volume 1 Issue 10.

15 Oct 2009 Parylene technology focus

Graduate student Christine Tan is interviewed and her work featured in a special article "Uses of Microarrays Increasing Rapidly", in the 15 Oct issue of Genetic Engineering & Biotechnology News (GEN).

1 Oct 2009 Piezoresistive transduction in multilayer polycrystalline silicon resonators

A new paper has been published by J. D. Cross et al. in the journal Applied Physics Letters. These resonators, fabricated from highly doped polycrystalline silicon layers separated by a dielectric layer, effectively transduces their mechanical motion as a vertical piezoresistor.

17 Sept 2009 Poster award at Cornell NanoScale Facility Annual Meeting

Congratulations to Ben Cipriany for winning an award based his work "Single-molecule studies of native chromatin."

15 Sept 2009 A method for nanofluidic device prototyping using elastomeric collapse

A new paper has been published by S.-M. Park et al. in the journal PNAS, demonstrating a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures.

3 Sept 2009 Labeling and purification of cellulose-binding proteins for high resolution fluorescence applications

A new paper has been published by Jose M. Moran-Mirabal et al. in the journal Analytical Chemistry, demonstrating a new protocol for labeling cellulases with three different fluorophores and their purification and separation of the labeled products.

27 Aug 2009 Parylene peel-off arrays to probe the role of cell–cell interactions in tumour angiogenesis

A new manuscript has been published by C. P. Tan et al. in the journal Integrative Biology. This work uses parylene as a stencil in order to pattern arrays of material which cells preferentially bind to. By simply varying the size and spacing of these arrays, the communication between single and groups of cells can be studied as a function of cell number and spacing, which should continue to give insights into tumor cell behavior and angiogenesis.

18 Aug 2009 Detection of prostate specific antigen with nanomechanical resonators

A new paper has been published by P. S. Waggoner et al. in the journal Lab on a Chip, demonstrating the detection of prostate specific antigen, a biomarker used for prostate cancer detection. The molecule could be detected at concentrations as low as 50 fg/mL (1.5 fM) in undiluted serum.

15 Aug 2009 Prion Protein detection in serum using micromechanical resonator arrays

A new paper has been published by M. Varshney et al. in the journal Talanta, demonstrating the detection of Prion proteins in serum using secondary mass labeling.

22 June 2009 Micromechanical drumhead resonators for pressure sensing

A new paper has been published from D.R. Southworth et al. entitled, "Pressure dependent resonant frequency of micromechanical drumhead resonators," in Applied Physics Letters. These devices were found to be excellent pressure sensors, giving a linear response in frequency shift from pressures of roughly one hundredth of an atmosphere up to nearly 4 atmospheres.

5 June 2009 Stress and Silicon Nitride: A Crack in the Universal Dissipation of Glasses

A new paper has been published from D.R. Southworth et al.in Physical Review Letters. These devices were found to be excellent pressure sensors, giving a linear response in frequency shift from pressures of roughly one hundredth of an atmosphere up to nearly 4 atmospheres.

15 May 2009 Recent research selected for inclusion in the Virtual Journal of Nanoscale Science and Technology

A paper recently published by P. S. Waggoner et al., High-Q, in-plane modes of nanomechanical resonators operated in air, has been chosen for virtual publication in the May 18th issue of the Virtual Journal of Nanoscale Science and Technology, published by the AIP and APS in cooperation with others to compile outstanding research in this field across many journals.

This marks the second publication from the Craighead Group recently highlighted in this virtual journal, joining the recently published The relationship between material properties, device design, and the sensitivity of resonant mechanical sensors, included in the March 23rd issue.

05 May 2009 New paper published on high-Q, in-plane resonators operated in air

Recent results showing that side-to-side vibration of nanomechanical resonators feature high quality factors at atmospheric pressures have been published by P. S. Waggoner et al. in the Journal of Applied Physics, DOI:10.1063/1.3123767. These trampoline-shaped devices are promising for sensor applications at high/atmospheric pressures, and suggest that this in-plane resonant mode can be beneficial for other resonator designs as well.

28 Apr 2009 Recent aptamer publication featured as "Hot Article" by RSC

A recently published paper from S.-M. Park et al. in Lab on a Chip DOI:10.1039/b819905a has been featured on the Royal Society of Chemistry website as a "Hot Article." This work describes a microfluidic device used to select and purify aptamers using individually addressable sol-gel capture droplets which can capture specific aptamers but later be removed with integrated heaters. This chip-based method shows promising results for improving the way aptamers are developed and prepared.

07 Apr 2009 Sugar-based microfluidics paper featured on cover of Soft Matter

A recently published paper from Leon Bellan et al. using cotton candy to form dense microfluidic channels for artificial tissue in Soft Matter DOI:10.1039/b819905a has been featured on the front cover of issue 7 (Vol. 5, 2009).

09 Mar 2009 Relationship Between the Design and Sensitivity of Resonant Sensors

A new paper has been published by Philip S. Waggoner and Harold G. Craighead in the Journal of Applied Physics, DOI:10.1063/1.3079793, looking into how resonator design affects the detection mechanism and sensitivity of the sensor. Notably, traditional cantilever devices were shown to not always be the most sensitive, and it was suggested that in most resonant biosensing applications, only the bound mass would be detected rather than stiffness.

Update: This paper has been selected for inclusion in the 23 Mar 2009 issue of the Virtual Journal of Nanoscale Science & Technology.

03 Mar 2009 RSS News Feed now available

Now recent news and publications from the Craighead Group can now be read using RSS 2.0/XML news feed! Subscribe using the xml link above.

27 Feb 2009 New Craighead Group Website Launched

The website has been given a new look, the content has been updated, and some improved features and content have been added. It will continue to be polished in near future, and older content archives will be posted gradually. If you have comments or suggestions, please send a note to the webmaster.

25 Feb 2009 Cotton Candy Can Help Labs Grow Tissue, featured in Discovery News

In an effort to improve the relatively thick artificial tissue implants, a cotton candy based approach has been developed to form a widespread and interconnected network of microfluidic channels. This research was published by Leon M. Bellan et al. in the journal Soft Matter DOI:10.1039/b819905a

This work was also highlighted in a video feature on the Discovery Channel program Daily Planet.